WebJul 7, 2024 · Objective . To investigate the protective effect and molecular mechanism of nuclear factor E2-related factor 2 (Nrf2) pathway in interstitial cystitis (IC). Methods . We established a mouse model of IC by cyclophosphamide (CYP) in wild-type mice and Nrf2 gene knockout mice. We examined the histological and functional alterations, the … WebDec 15, 2024 · We used cyclophosphamide to induce IC/BPS in rats, and intravesical instillation of 10% dextrose solution was performed. After 1 week, we conducted a urodynamic test, bladder staining, and ECM-related gene expression analysis to examine the treatment’s efficacy.
Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced …
WebPrevention of Ifosfamide Induced Hemorrhagic Cystitis. 240 mg/m² (if receiving 1.2 g/m² ifosfamide dose) IVP 15 minutes before & 4 & 8 hours after ifosfamide admin OR . ... Prevention of Cyclophosphamide Induced Hemorrhagic Cystitis (Off-label) 20% of cyclophosphamide dose when injected, 4 and 8 hours after each dose. Safety & … WebMaterials and methods: Cystitis was induced in 6 female mice by an intraperitoneal injection of cyclophosphamide (300 mg/kg). Voiding frequency, void volume, hematuria assessment, and ultrasonographic measurements of the bladder were obtained at baseline, days 1 to 5, and days 9, 11, and 13. hr tech orlando
Cyclophosphamide-induced intractable hemorrhagic …
WebFeb 25, 2024 · Background: The involvement of the vagus nerve in the supraspinal neural circuits that control the urinary bladder function, especially during pathological conditions, became increasingly evident. However, the role of brainstem areas in these circuits is not studied yet. Methods: In the present study, using c-fos immunohistochemistry, the roles … WebApr 26, 2024 · Interstitial cystitis (bladder pain syndrome, Hunner ulcer) is a painful bladder disease characterized by chronic urinary urgency, frequency, and pain without evidence of bacterial infection.... WebCyclophosphamide (CP) is a widely used anti-neoplastic drug; however, it leads to bladder dysfunction in the form of hemorrhagic cystitis that is a serious dose-limiting complication in cancer patients. We aimed to evaluate the protective effects of metformin (MET) in a mouse model of CP-related cys … hrtechnology business analyst