Cytological profiling

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August undefined, 2024

WebDec 2, 2013 · Computational methods for image-based profiling are under active development, but their success hinges on assays that can capture a wide range of … WebDec 9, 2015 · We have used cytological profiling to determine the cellular target for four newly purified or partially characterized compounds, including the cannibalistic sporulation delaying protein (SDP ...

Cytological profiling: providing more haystacks for …

WebBacterial cytological profiling (BCP) is a rapid and powerful approach to identify the cellular pathway affected by antibacterial molecules. As a one-step assay, BCP presents … WebApr 12, 2024 · At the cellular level we used advanced imaging and electrophysiology techniques to determine if there is an aging-related decline in mechanoelectrical and … remarkable cdiscount

[PDF] Application of bacterial cytological profiling to crude natural ...

WebApr 12, 2024 · Using RNA-seq, advanced imaging, and electrophysiology, Liu et al. reveal molecular and cytological profiles of aging cochlear hair cells. Their study also suggests that a functional decline in mechanotransduction and cochlear amplification precedes hair cell loss and contributes to age-related hearing loss. WebDec 1, 2024 · The other platform, a cytological profiling (CP) technology developed by Lokey's lab, involves high-content image analysis of cells exposed to the samples being screened and then stained with a ... WebBacterial Cytological Profiling (BCP) as a Rapid and Accurate Antimicrobial Susceptibility Testing Method for Staphylococcus aureus Authors : D.T. Quach 1,4 , G. Sakoulas 2 , V. … remarkable chest genshin wiki

Cytological profiling

WebApr 11, 2024 · Besides conventional growth inhibition assays, an interesting emerging technique is cytological profiling, which allows ‘function-first’ mining of natural products with desired biological activities by predicting the mechanisms of action based on microscopy analysis of the cellular responses of target strains (Nonejuie et al. 2013; … WebCytological profiling of the afforded natural products against PD hONS cells revealed 34 compounds strongly perturbated the staining of several cellular organelles. In fact, greaterthan 1.5-fold change was observed compared to the control (dimethyl sulfoxide; DMSO), with early endosome, lysosome, and autophagosome (LC3b) being particularly …

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WebSep 18, 2024 · Screening ecosystems containing at least one antiviral sample cytological profile were cross-referenced to cytological profiles obtained by the same method from a library of 720 bioactive reference compounds (Bray et al. 2024; Pennisi 2016). Orthogonal analyses using cytological profiling revealed HIV-inhibitory MeE samples in four major … WebJan 21, 2024 · We recently developed Bacterial Cytological Profiling (BCP) as a new whole-cell screening technique that can be used to rapidly identify the mechanism of action (MOA) of antibiotics [11–16]. BCP can accurately identify the pathway inhibited by antibacterial compounds present in unfractionated crude organic extracts and can be …

WebCytological profiling (CP) is an unbiased image-based screening technique that uses automated microscopy and image analysis to profile compounds based on numerous … WebBacterialcytologicalpro lingrapidlyidenti esthecellularpathwaystargetedbyantibacterialmolecules. PoochitNonejuiea,MichaelBurkartb,KitPoglianoa,andJoePoglianoa,1

WebApr 12, 2024 · Age-related hearing loss (ARHL) negatively impacts quality of life in the elderly population. The prevalent cause of ARHL is loss of mechanosensitive cochlear … WebSep 17, 2013 · Cytological profiling in eukaryotic cells relies upon measuring a large number of cytoskeletal markers . Because bacteria are 100 times smaller than the typical …

WebDec 9, 2015 · We have used cytological profiling to determine the cellular target for four newly purified or partially characterized compounds, including the cannibalistic …

WebJan 18, 2016 · We have developed a rapid antimicrobial susceptibility assay for Staphylococcus aureus based on bacterial cytological profiling (BCP), which uses … remarkable business cardsWebAug 22, 2024 · Understanding the mechanism of action (MOA) of new antimicrobial agents is a critical step in drug discovery but is notoriously difficult for compounds that appear to inhibit multiple cellular pathways. We recently described image-based approaches [bacterial cytological profiling and rapid inducible profiling (RIP)] for identifying the cellular … remarkable cabinets cut bankWebJul 29, 2005 · Cytological profiling: providing more haystacks for chemists' needles Abstract. Conventional high-throughput 'chemical genetic' screening seeks to identify small … professional negligence third partyWebFeb 25, 2024 · 2 23 Importance: We demonstrate that bacterial cytological profiling is a powerful tool for directing antibiotic discov- ery efforts because it can be used to … professional negligence ttlawcourtsWebHigh-content screening (HCS) in cell-based systems uses living cells as tools in biological research to elucidate the workings of normal and diseased cells. HCS is also used to discover and optimize new drug candidates. High content screening is a combination of modern cell biology, with all its molecular tools, with automated high resolution … professional negligence in tort lawWebthe multiplex cytological profiling protocol, images were captured at 20x magnification with an automated epifluorescent microscope. We extracted 824 morphological features … professionalnetworkersfacebookWebMay 1, 2016 · Bacterial cytological profiling is a powerful tool for directing antibiotic discovery efforts because it can be used to determine the specificity of an antibiotic's in vivo mechanism of action and demonstrates that BCP can identify multiple pathways that are inhibited by an individual molecule. remarkable case