WebNov 1, 2024 · RPAP3 inhibitors: dictyoceratin-A and -C. RPAP3 inhibitor was isolated from sea sponge living in the Indonesian sea. Arai and the colleagues isolated eight sesquiterpene phenol/quinones including dictyoceratin-A and -C from Dactylospongia elegans by searching for differentiation-inducing compounds in human chronic … WebMay 31, 2024 · Dictyoceratin-C; Agelasine D; Download chapter PDF 1 Introduction. Pathways for exploring bioactive natural products in the quest for novel drug discovery “seeds” may be broadly classified into two categories: target-specific screening and phenotypic screening. Target-specific screening identifies compounds effective for an …
Structure-Activity Relationship and in Vivo Anti-Tumor …
WebDec 16, 2015 · Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure-activity relationship of the natural compounds 1 and 2 isolated from a marine sponge. WebDec 16, 2015 · Abstract: Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activity relationship of the natural compounds 1 and 2 isolated from a marine … philips carbonating bottles
Uncommon Bis‐quinolizidine Alkaloids from the Hainan
WebDOI: 10.1016/S0040-4020(01)87643-2 Corpus ID: 92510326; Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp. @article{Nakamura1986DictyoceratinAA, title={Dictyoceratin-A and -B, Novel Antimicrobial Terpenoids from the Okinawan Marine Sponge sp.}, author={Hideshi Nakamura and … WebThe marine spongean sesquiterpene phenols dictyoceratin-A (1) and -C (2) have been shown to induce hypoxia-selective growth inhibition in cultured cancer cells and exhibit in … WebJul 1, 2015 · Dictyoceratin-C (1) inhibited proliferation of human prostate cancer DU145 cells selectively under hypoxic condition in a dose-dependent manner at the concentrations ranging from 1.0 to 10 μM. The subsequent structure–activity relationship study using nine sesquiterpene phenol/quinones ( 2 – 10 ), which were isolated from marine sponge ... philips car air purifier india